Be sure of what you are buying!

Pau d'arco or Taheebo is not all created equally.

The unfortunate truth is that many  products are not even true Pau d'arco.


Research has been done showing that some alleged Pau d'arco products actually contain only sawdust from other rain forest trees and no Pau d'arco. If you put your faith in these products to improve your horses health you are  wasting your money and, most importantly, your time.

The Pau d'arco you use must come from the inner bark of the correct species of tree and it must be processed properly.

Meadowsweet Acre Herbals only uses and sells pure Pau D'arco tree bark.




 

Pau D'arco Properties
I will try to explain WHY Paul D'arco maybe beneficial to the EPM horses. Researchers have isolated the most active immunostimulants in the bark, including veratric acid and various plant pigments called "Quinines". Small quantities of two of these quinones combined, forces T-cell proliferation by more than 40 percent. They also isolated a yellow crystalline pigment called lapachol, which has proven effective against malaria-like symptoms.
T-cells have long been the main suspect in a dysfunctional immune system. When their population decreases or their functional ability becomes hampered, the antibody-forming B-cells that they regulate have a more difficult time distinguishing the harmful effects of toxic substances from harmless substances entering the body.
Quinones are found throughout nature, and are considered extremely important. Quinones are primarily involved in the biological transfer of hydrogen and electrons. Quinones help in the process of oxidative metabolism in plants and animals. What Does all this Mean?

In a nutshell, research has found that Pau D'arco tree bark  quinones can boost the immune system and that lapachol will help fight protozoan type invaders. This is the first "herb" that has been found to fight protozoan type problems. There is also Chincona Bark, which also contains quinones and has anti-protozoan properties, but research has found the bark to be too caustic for horses to tolerate. It will cause severe stomach upset and colic. Pau D'arco , on the other hand, seems to be a safer choice all the way around with few side affects.
It must be noted that LARGE dosages were LESS immunostimulating than smaller ones, which is typical of immunostimulants in general. Lower versus higher doses and concentrations of Pau D'arco were also more effective .


The Following is an Excellent article by Dr. Mowry

Pau D'arco {Teehebo}
Ancient Herb, Modern Miracle
This pamphlet attempts to explain the meaning behind the stack of research that has been published concerning the anti-cancer, antiviral and other properties of the South American herb known as Lapacho. While a much larger volume could be written about the empirical data that has been collected around the world on the almost unbelievable properties of this plant, my chief concern is with the experimental, medical and clinical data that bears a more certain scientific aura.

One of the last great, but largely untapped, reserves of natural resources on the face of the earth is South America. The herbal medicines that abound on this continent have been largely denied to the rest of the world; the inaccessibility of the great forests, combined with a general lack of interest, have
kept the secrets of the region shrouded in darkness. Africa is a continent of light by contrast.

Efforts to increase the availability of South American herbal remedies have been extremely arduous and difficult. Only with great effort are we able to bring together all the resource necessary to successfully identify, harvest and export such plant materials. Much material coming into the U.S. from its southern neighbors has been falsely identified, or adulterated,or harvested incorrectly. Rare is the importer who even knows what to look for.

Nowhere have these difficulties been more apparent than in the marketing of lapacho. Lapacho (Tabebuia avellandedae, & T.impetiginosa) comes from the rain forests and mountains of Paraguay, Argentina and Brazil. We have known about this plant for almost 100 years, yet efforts to import medicinally active lapacho have failed more than they have succeeded. In spite of the difficulties, the interest remains extremely high, because this plant holds great promise for the effective treatment of
cancers such as leukemia, candida and other troublesome infections, debilitating diseases (including arthritis), as well as a host of other complaints.

Anyone familiar with the recurring ginseng and goldenseal fiascoes will appreciate the similar state of affairs that exists in the business of lapacho. In fact the chances of obtaining good quality ginseng and goldenseal in American health food stores are greater than the odds of obtaining good quality lapacho. A vast majority of commercial lapacho is void of significant activity. The reason is primarily lack of quality control at every stage of the enterprise; gatherers, unaware as to which parts of the plant contain the active material, harvest all parts of the plant; curers, unaware of the traditional lapacho curing practices, make assumptions that are more often wrong than right; shippers pay little attention to protecting the material from the hazards of transportation; manufacturers, unaware of what constitutes really good lapacho (having never bothered to go to South America and have a look), don't have any
idea how to set up quality control or standardization practices that guarantee activity.


Description

Lapacho is an evergreen tree, with rosy colored flowers, belonging to the Bignonia family. Nearly 100 species of lapacho trees are known, but only a few of these yield high quality material, and it takes extremely skilled gatherers to tell the difference. (Half or more of the battle involved in bringing high quality lapacho to the marketplace is finding and retaining qualified gatherers.) The medicinal part of the tree is the bark, specifically the inner lining of the bark, called thephloem (pronounced floam). The use of whole bark,containing the dead wood, naturally dilutes the activity of the material. Lapacho is also known by the Portuguese name of Pau D'Arco, and by tribal names such as Taheebo and Ipe Roxo. Some texts distinguish between Lapacho Colorado (red lapacho-ipe roxo) (scarlet flowers) and Lapacho morado (purple lapacho) which grows in cooler climates such as high in the Andes, and high places in Paraguay. Recent evidence suggests that these two varieties of lapacho possess superior medicinal properties, with a slight bow going to the purple as the best of all.

Constituents

Most of the chemical analyses of lapacho have been performed on the heartwood of the tree, rather than on the phloem, or inner lining of the bark, which is used medicinally. It is unclear why this has occurred. One reason may be that the heartwood contains enough quantities of a couple of important constituents, mainly lapachol and tabebuin, to satisfy current research interests. Once the therapeutic activity of those constituents has been thoroughly investigated, perhaps researchers will turn their attention to the phloem. Until then, it is probably safe to assume that the living bark contains a similar set of active constituents as the heartwood plus some others that make it more effective and would account for the living bark's greater popularity as a folk medicine. Traditionally, as anyone who chooses to examine the herbal literature of the world can verify, it is the living bark of a plant, especially a tree or shrub, that is used medicinally--not the heartwood. The reason is simple: the nutrients and representative families of chemical substances used to sustain the life of the tree are found in greatest concentration in the cambium layer and phloem of the living bark.
The life processes of a mature tree are carried out in the thin corridor lying between the outer bark and the inner heartwood.

Pull the bark off a tree and you will notice moist, very thin layers of tissue that seem to shred when picked at with the hands. This is the cambium layer. Its purpose is to create new tree tissues, such as phloem, through cell division. The newest, youngest phloem cells are just outside the cambium. As new phloem is added, older cells are crushed and pressed into the bark.

Younger, newer cells added to the inside of the cambium layer are called xylem. Newer xylem is called sapwood; older xylem is crushed and pressed into the heart of the tree. It is therefore known as heartwood. The actively conducting tissues of a tree are the thin layers of fresh xylem and phloem on each side of the cambium. The outer bark and heartwood are essentially, inactive materials that only serve to provide strength to the tree. Indiscriminate combining of older, less active layers of bark and tree with the younger, living tissues results in a dramatic dilution of active principle and medicinal value. Yet it is a common practice. Lapachol is just one of a number of plant substances known as napthaquinones (N-factors) that occur in lapacho. Anthraquinones, or A-factors, comprise another important class of compounds. The N-factors are not common except in herbal tonics. Seldom do both N- and A-factors occur in the same species. Several of the remarkable properties of lapacho may be due to a probable synergy between A- and N- factors.Quercitin, xloidone and other flavonoids are also present in lapacho; these undoubtedly contribute to the plant's effectiveness in the treatment of tumors and infections.

Folklore

The native Indians of Brazil, northern Argentina, Paraguay, Bolivia and other South American countries have used lapacho for medicinal purposes for thousands of years; there are indications that its use may actually ante-date the Incas. Before the such as arthritis and prostatitis, and circulation disturbances., Other conditions have reportedly been cured with lapacho including lupus, diabetes, Hodgkins disease, osteomyelitis, Parkinson's disease, and psoriasis. It is used to relieve pain, kill germs, increase the flow of urine, and even as an antidote to poisons. Its use in many ways parallels that of the immuno-stimulants echinacea on this continent and ginseng in Asia, except that its action appears to exceed them both in terms of its potential as a cancer treatment. The Guarani, Tupi and other tribes called the lapacho tree "Tajy," meaning "to have strength and vigor,or simply: "The Divine Tree". Modern Guarani Indians prefer the purple lapacho, but also use the red lapacho. And they use only the inner lining of the bark. The use of lapacho may not be limited to tropical countries. A Yugoslavian scientist, Voislav Todorovic, claims that he has found evidence that the plant was used by the Vikings and the Russians. He also claims that a Russian chemist (in the late 1800's) manufactured a toothpaste that contained lapacho that was supposed to have been extremely effective in preventing tooth decay.

Early Scientific Work

Research on lapacho has been going on for a long time. E. Paterno isolated the active constituent, lapachol, in 1884. Inn 1896, S.C. Hooker established the chemical structure of lapachol, and L.F. Fieser synthesized the substance in 1927! So it would be a mistake to call lapacho a modern discovery.

As early as 1873, physicians were aware of the healing action of lapacho. Dr. Joaquin Almeida Pinto wrote during that year, "Pau D'Arco: Medicinal Properties: prescribed as a fever-reducer; the bark is used against ulcers; also used for venereal and rheumatic disorders and especially useful for skin disorders, especially eczema, herpes and the mange."/4 Another early physician, Dr. Walter Accorsi, reported that lapacho, "eliminated the pains caused by the disease (cancer) and multiplies the body's production of red corpuscles."

However, the science of lapacho began properly with the work of Theodoro Meyer in Argentina who tried for decades with little success to convince the medical world of the value of lapacho for infections and cancer. Data from his laboratory are astounding in terms of the success rate observed when applying the herb in dozens of different kinds of cancer. Much of Meyer's work was primitive by modern research standards; most of it lacked adequate controls and statistical evaluation. But the sheer bulk of it is good evidence for the efficacy of lapacho. The Meyer era ended at his death in 1972, with the scientific world left still largely unconvinced of the usefulness of lapacho as a modern medicinal agent. Perhaps the most important thing Meyer accomplished, from a scientific point of view, was to bring lapacho to the attention of the rest of world, to extract the plant from the jungles of the Amazon, and announce, "Here is a folk remedy with great promise for all mankind."

Independent of Meyer, a physician in Brazil, about 1960, after hearing a tale of its miraculous curative powers, used lapacho to treat his brother who was lying in a Santo Andre, Brazil hospital, dying of cancer. His brother recovered, and the physician, Dr. Orlando dei Santi, began to use the herb to treat other cancer patients at the hospital. Other physicians joined the team, and after a few months, several case histories of cures were recorded. In the typical case, pain disappeared rapidly and sometimes complete remission was achieved in as little as four weeks.
Because of the work at the Municipal Hospital of Santo Andre, lapacho has become a standard form of treatment for some kinds of cancer and for all kinds of infections in medical establishments throughout Brazil. It should be noted that after the first reports of "miraculous" herbal cures appeared in Brazil, the national government ordered a blackout of any more public statements by doctors involved in the research. The silence was finally broken by Alec De Montmorency, who in 1981 published a lengthy review of the ongoing clinical work in Brazil. This report succeeded in stimulating worldwide interest in the plant.

In 1968, Dr. Prats Ruiz of Concepcion, Argentina, successfully treated three cases of leukemia in his private clinic. Some of these results were widely published and also helped to establish the popularity of lapacho among the "civilized" inhabitants of South American countries.
American physicians, of course, tend to look disparagingly upon the clinical evidence from backward areas of South America, preferring instead sanitized evidence from their own brightly lit laboratories. The weight of the South American clinical evidence has not been sufficient to cause widespread acceptance of the treatment outside South America, but it has stimulated research interest abroad. Pharmaceutical companies regularly screen lapacho for the presence of substances that could be the basis for new drug applications. As we shall see, however, no isolated component of lapacho comes anywhere close to being equal to the combined activity of all constituents, or, in other words, to the whole herb.

Drug Detox Observations
A common thread that runs throughout early and current empirical and clinical reports of lapacho treatment is the consistent observation that the herb eliminates many of the common side effects of the orthodox medications. There is no explanation of this action, but it is so often seen that one cannot easily doubt its validity. Pain, hair loss and immune dysfunction are among the symptoms most commonly eliminated.

Modern Investigative Work
While scientific research on lapacho has been going on for decades, most of it is worthless from a medicinal point of view. Some of it, however, is very good, and has resulted in the isolation of several individual medicinally active constituents and in the analysis of their properties. The current interest in AIDS has stimulated renewed interest in lapacho since the herb is such an effective anti-viral substance.

The main problem with American research on the plant is the tunnel-vision with which the work is engaged. Without any understanding of the ultimate source of the plant's effectiveness, researchers routinely isolate what they think should be the active component and apply it is standard screening trials. The results of such research are sometimes positive, sometimes negative, sometimes strong, sometimes weak--always inadequate, by definition. It didn't surprise anyone that the trials performed by the National Cancer Institute were less than convincing. And it also didn't surprise anyone when that same institute rejected out-of-hand the highly positive results obtained by many non-American researchers who utilized different methods. The self-serving tendency of the American medical/regulatory establishment to accept only its own research is indulged by the rest of the world's scientific community with polite and somewhat amused patience, as they wait for America to grow up.

The following is a summary of some of the effects of lapacho and/or any of its constituents that have been validated by modern research:

1. Laxative effect. Regular use of lapacho will maintain regularity of bowel movements. This property is undoubtedly due to the presence of the napthaquinones and anthraquinones. Users of lapacho universally report a pleasant and moderate loosening of the bowels that leads to greater regularity without any unpleasant side-effects such as diarrhea.
2. Anti-cancer effect. The greater part of the basic research on lapacho, both in the United States and in other countries has dealt directly with the cancer question. Obviously, this issue is of great importance. Any tendency of lapacho to ameliorate the course of cancer should be made known to all persons likely to benefit from it. The absence of side effects makes lapacho a treatment of choice even in conjunction with standard forms of therapy. The user has nothing to lose and much to gain from the judicious use of lapacho. Naturally, any and all treatment of a cancerous condition should be done under the supervision of a qualified physician.
Some constituents or groups of constituents of lapacho have indeed been found to suppress tumor formation and reduce tumor viability, both in experimental animal trials and in clinical settings involving human patients. In addition, anecdotal data abounds to such an extent that to overlook its importance is to turn one's back on a potentially invaluable source of aid and health. Leukemia has proven particularly susceptible to the application of lapacho and several of its constituents. Some researchers feel that lapachol is one of the most important anti-tumor agents in the entire world.

"I had a large tumor in my brain. Traditional treatment produced only minor success. Then I began to use lapacho tea. After several weeks a CAT scan showed that the tumor was totally gone. The doctors couldn't believe it because they had classified my case as basically untreatable."
Part of the effectiveness of lapacho may stem from its observed ability to stimulate the production of red blood cells in bone marrow. Increased red blood cell production would improve the oxygen-carrying capacity of the blood. This, in turn, could have important implications for the health of tissues throughout the body. Also needed for oxygen transport by red cells is iron. This might explain the augmentation in lapacho's therapeutic properties when it is combined with iron-rich yerbamate, another South American plant; in fact, it is native practice to almost always combine these two plant species.

3. Anti-oxidant effect. In vitro trials show definite inhibition of free radicals and inflammatory leukotrienes by lapacho constituents. This property might underlie the effectiveness of lapacho against skin cancer, and definitely helps to explain observed anti-aging effects. Modern science has recently uncovered the importance of free radicals in the generation of many debilitating diseases, from cancer to arthritis. These molecules are even heavily implicated in the normal aging process. Reversing their action has become big business in world health circles. Anti-oxidants, or free-radical scavengers, have emerged as premier candidates for the role of healers and disease-preventers. Among the antioxidants few have greater potency than lapacho and other constituents of lapacho.

4. Analgesic effect. The administration of lapacho is consistently credited in reports issuing from South American clinics as a primary modality for lessening the pain associated with several kinds of cancer, especially cancer of the prostate, liver or breast. Arthritic pain has also been relieved with lapacho ingestion.

5. Antimicrobial/anti-parisiticidal effects. includes inhibition and destruction of gram positive and acid-fast bacteria (B. subtilis, M. pyogenes aureus, etc.5-8), yeasts, fungi, viruses and several kinds of parasites. Two troublesome families of viruses inhibited by lapachol are noteworthy: Herpes viruses and HIV's. Together, these viruses account for much of the misery of mankind. The anti malarial activity of lapacho spawned a great deal of research interest in the early decades of this century. A 1948 article reviewed the progress and indicated that the N-factors, especially lapachol, were among the most promising anti malarial substances known at that time. Lapacho's immunostimulating action is due in part to its rather potent antimicrobial effects.

"I began using yerbamate and lapacho tea about 3 mos. ago. I immediately experienced a surge of energy . . . within half-an-hour I was up dancing which is pretty amazing considering I've got MS and spent most of the Spring in a wheelchair. Within 2 days I noticed a lessening of pain and muscle spasms which was fantastic . . . my urinary, bowel and digestive functions have vastly improved . . . There is no doubt that the MS has greatly improved with the herbs as I quit using them for a week and all the old symptoms return. I start the tea again and they subside., I've repeated this scenario three times."
6. Anti-fungal effect. Lapacho is often singled out as the premier treatment for Candida or yeast infections. Lapachol, N-factors and xyloidone appear to be the primary active principles.9/10 By the mid 70's the list of N-factors that inhibited Candida albicans and other fungi had grown to several dozen.

It would be misleading to categorically state that the N-factors in lapacho have proven antimicrobial and anti fungal activity in and of themselves. Studies have shown that the manner in which they occur in the plant must be taken into consideration. We know, for example, that anti fungal activity is lost when the N-factors are tightly bound to highly water-soluble or highly fat-soluble groups. It has not been clearly determined how the N-factors occur in lapacho.16
N-factors, obtainable from various chemical supply companies, have become favorite testing agents in government/university labs due to the rise in yeast infections resulting from increased use of cytotoxic drugs, corticosteroids, antibiotics and immunosuppressants.17-18
An interesting application has been reported in which toe and fingernail fungi infections are relieved by soaking these appendages in lapacho tea off and on for a couple of weeks.

7. Anti-inflammatory. The anti-inflammatory and healing action of lapacho extracts was demonstrated in a study in which purple lapacho extract was administered to patients with cervicitis and cervico-vaginitis, conditions resulting variously from infections (candida albicans, trichomonas vaginalis), chemical irritations and mechanical irritation. The lapacho extract was applied intra-vaginally via gauze tampons soaked in the extract, and renewed every 24 hours. The treatment proved to be highly effective.19 One wonders what might happen were the tampon method combined with the ingestion of strong teas.
The anti-inflammatory action of lapacho might also account for its observed tendency to reduce the pain, inflammation and other symptoms of arthritis. Anecdotal accounts of complete cures are even available. As yet virtually untested in research settings, the purported ability of this plant to reduce symptoms of joint disease may be ultimately validated and added to the growing list of benefits to be enjoyed by the daily ingestion of lapacho tea.
"I recently had a violent M.S. attack. I lost my balance, lost vision in my left eye and had excruciating pain in my left leg. I went to bed, took the anti-siezure medication and an analgesic. I drank about 1-1/2 quarts of lapacho and mate. Within 6 hours I was up stuffing turkey. Usually these episodes lay me up for weeks. I am convinced the lapacho and mate made the difference."

8. Other beneficial effects. Routine screenings have revealed several minor properties of lapacho that might occur if needed in certain individuals: diuretic, sedative, decongestant, and hypotensive, to name a few.



ANTI-VIRAL
One of the strongest actions of lapacho is against viruses. The range of viruses inactivated by lapacho extends from those that cause the common cold to those that are responsible for AIDS. It has been shown to actively inhibit, kill or stunt the growth of several dangerous viruses, including herpes virus hominis types I and II, polio virus, vesicular stomatitis virus, avian myeloblastosis virus, rauscho murine leukemia virus, friend virus, and rous sarcoma virus. 20-24 Several other viruses are also inhibited by lapacho's N- and A-factors.

One N-factor, beta-lapachone, inhibits enzymes in virus cells that directly affect the synthesis of DNA and RNA. It is also a potent inhibitor of the enzyme reverse transcriptase, involved in RNA/DNA relationships. Once these processes are inhibited, the virus is unable to take over the reproductive processes of the cell and cannot, therefore, replicate itself and infect other cells. Such inhibition is a characteristic of most substances that are being tested for activity against AIDS and Epstein-Barr. The enzyme in question is a key to the action of retroviruses. These viruses, also known as ribodeoxyviruses or oncornaviruses, have been implicated in the development of several kinds of experimental cancers. Beta-lapachone is obtained simply by treating lapachol with sulfuric acid, and tests show that it has a unique method of action vis-a-vis the reverse transcpritase inhibition.


ANTI PARASITIC
Lapacho components have been intensively studied in terms of their action against two rather nasty parasites: Schistosoma mansoni and Trypanosoma cruzi, both responsible for considerable disease and misery in tropical countries. Lapacho was effective against both.26-28
Taken by mouth, lapachol is eventually secreted onto the skin via the sebaceous glands where it acts as a topical barrier, inactivating microorganisms soon after they contact the skin. Meanwhile, throughout the G.I tract, it is performing the identical function on the mucous membranes, preventing the penetration of parasites. The mechanism of action is not well understood, but is felt to involve the uncoupling of cellular respiration (see Cellular Mechanics Section), the stimulation of lipid peroxidation and super oxide production, and the inhibition of DNA/RNA biosynthesis.

CANCER
Lapacho has been extensively investigated for potential anti-cancer activity. Even the National Cancer Institute has gotten in the act, but in their own typical way, they managed to drop the ball before achieving success. They restricted their investigations to lapachol, and once they found that this substance had side effects that offset its potential therapeutic benefits, they abandoned the project. The holistic practitioner readily perceives the fallacy of that approach, and is skeptical of applying isolated herbal constituents. As if in conformation of that skepticism, research that involved whole lapacho has produced clinical anti-cancer effects without side effects.

Animal research in the United States made a gigantic stride forward when it was discovered that lapachol inhibited solid tumors (Walker carcinosarcoma 256 and Ehrlich solid carcinoma) and Ehrlich ascites cell tumors.31 Such research then took a gigantic stride backwards when clinical toxicity of lapachol prematurely ended these investigations.

One interesting line of research has shown that lapachol is more effective when ingested orally, rather than injected into the gut or into the muscles. These results contradict a substantial amount of research on orthodox drugs that indicates the superiority of injectable routes. What is the meaning of this anomaly? Could it be a sign that natural routes of administration (i.e., oral) are better suited for natural substances? The further removed from the natural state, the more active substances become when injected directly into the blood stream, and the less able the natural processes of the body are in dealing with them.

Using the wood of the plant, several researchers have studied the effects of lapachol, alpha- and beta-lapachone and xyloidone on experimental cancer (Yoshida's sarcoma and Walker 256 carcino-sarcoma). As high as 84% inhibition was observed on Yoshida's sarcoma. And no toxicity was found.

In one clinical study,33 South American researchers administered lapachol to patients with various forms of cancer, including adenocarcinoma of the liver, breast and prostate, and squamous carcinoma of the palate and uterine cervix. Taken orally, the substance resulted in temporary reduction of all conditions and in a significant reduction in pain. Duration of treatment was anywhere from 30 to 720 days, with an average of about two months. For example, one patient with liver cancer presented with a significant reduction in jaundice accompanied by other signs of improvement after eight days of therapy. These results were in close accord with results obtained by the same researchers in animal studies.34 One wonders what the administration of whole purple lapacho phloem might have accomplished in this setting; other lines of evidence suggest that even better results may have been obtained.

"During exploratory surgery it was noted that I had ovarian, stomach, intestine & liver cancer. I was told I had approximately 4 to 6 months to live. I made up my mind to fight. I went for chemotherapy, drank a quart of red lapacho tea, an ounce of aloe vera juice and took various vitamins daily. After 11 mos. the physicians could not believe what they found (no cancer). I continue to have regular check-ups and have proved to be a 'miracle case'."

A Note on Nausea: In the human study reported above, some patients dropped out of the experiment due to nausea. This is a common observation in some, but certainly not all, people who begin to experience the cleansing action of lapacho (and other healthful herbs). As toxins (and toxic medicines) and wastes are drawn out of the cells, or flushed out, or physiologically expelled from the cells, through the action of the herb, they tend at times to accumulate in the blood, lymph, lymph nodes, skin, liver and kidneys awaiting the opportunity to be expelled from the body. Backing up, they can, on occasion produce sensations such as nausea; the body may even try to rid itself of some toxic substances by vomiting. Not to worry. These transient signs dissipate once the toxins are moving freely from the body. They are a positive sign that the herb is working. Remember the body only has three basic processes for getting rid of wastes: lower bowel movement, sweating, urinating. The use of lapacho can so overload these processes in the early stages that discomfort may be produced.


CELLULAR MECHANICS
Every cell of the body requires oxygen and glucose to obtain energy for life-sustaining functions. The oxygen and glucose are subjected to a fairly complex metabolic process in the tiny energy producing structures in the cell called mitochondria. This process requires numerous enzymes and coenzymes. The oxygen and glucose are converted to carbon dioxide and water which are then returned to the blood. the CO2 is exhaled by the lungs (hence this metabolic process is often called "respiration"); excess water is eventually drawn off through perspiration or through the kidneys. During this conversion, several free electrons are freed up, which are immediately utilized by another pathway to produce ATP (adenosine triphosphate), the energy currency of the cell--ATP is the molecule every cell is required to utilize, or spend, to obtain energy. The two paths--one for breakdown of glucose, and one for synthesis of ATP--are tightly coupled together. Should they become uncoupled, the cell can no longer obtain energy, and it dies. Such poisoning has acquired the name of "uncoupling of oxidative phosphorylation."

Many agents have been found that uncouple oxidative phosphorylation; many of them resemble the N-factors in lapacho. In fact, it has been found that lapacho works like other benzoquionones, i.e., it uncouples the mitochondrial oxidative phosphorylation occurring in cancerous cells, but not in healthy ones.35 This selective killing (cytotoxicity) of tumor cells is what makes lapacho such a potentially valuable agent for the treatment of cancer.

One of the games science plays is attempting to discover at what point cellular respiration is broken up by chemical agents The components of lapacho seem to interrupt the process at several points, usually by inhibiting an enzyme or coenzyme that is required for the next step in the chain to occur properly.36-38 For instance, lapacho inhibits the proper functioning of ATPase, the enzyme that catalyzes the final step in the formation of ATP.

Lapachol has also been shown to inhibit the amount of another substance required for cellular reproduction: uridine triphosphate.40 This molecule is the main source of substances (called pyrimidine nucleotides) that are required by cells in order to build DNA, RNA and most other important proteins of the body. Lapacho may actually block the syntheses of pyrimidines in cancer cells (by inhibiting the enzyme dihydroorotate dehydrogenase).41 The result would be certain cellular death.

There is also evidence that lapachol interacts directly with the nucleic acids of the DNA helix in cancerous cells.42 If such interaction, or bonding, takes place then DNA replication would be impossible. The result is also eventual death of the cell.
Finally, lapacho constituent beta-lapachone has been shown to weaken malignant cells, even to the point of cellular death, by stimulating a process known as lipid peroxidation, which produces toxic molecules.

TOXICITY
While there can be no doubt that lapacho is very toxic to many kinds of cancer cells, viruses, bacteria, fungi, parasites and other kinds of microorganisms, the substance appears to be without any kind of significant toxicity to healthy human cells. The side-effects mainly encountered, and usually with isolated lapacho constituents, are limited to nausea and anticoagulant effects in very high doses, a tendency to loosen the bowels, and diarrhea in very high doses. As indicated earlier, some nausea should be expected as a natural consequence of the detoxification process. The FDA gave lapacho a clean bill of health in 1981.

Some trials have indicated that lapachol has anti-vitamin K action. Other constituents have a pro-vitamain K action; it is likely, therefore, that the two actions cancel each other out (except possibly when one or the other is necessary--as one would expect from an herbal tonic).
Perhaps the most significant study on toxicity was published in 1970 by researchers from the Chase Pfizer & Co., Inc. Looking specifically at lapachol, these investigators found that all signs of lapachol toxicity in animals were completely reversible and even self limiting, i.e., over time the signs of toxicity decreased and even disappeared within the time constraints of the study. The most severe kinds of self-limiting side-effects they observed were an anti-vitamin K effect, anemia, and significant rises of metabolic and protein toxins in the blood stream. The diminution of these signs indicates that lapacho initiates an immediate "alterative" or "detoxification" effect on the body's cells. Once the cells are "cleaned up," the signs of toxicity disappear. This effect is quite common among herbal tonics.

HOW MUCH AND WHEN
Lapacho can be used periodically as a preventative during colds and flu season, or whenever the chances for infections are high. Experience has taught that lapacho is best ingested as a tea, one or two cups a day, morning and evening. Used in this fashion, it promotes the health of the immune system, helps prevent the onset of colds and flus, keeps the bowel healthy and may impart some of the other important therapeutic effects, including a positive effect on arthritis, pain, localized infection (e.g. candida) and systemic infection.
During periods of acute, active infection, lapacho should be administered several times a day in tea form. It is up to the individual to determine the optimum amount for him or her. It is not uncommon for a person's awareness of his or her personal health needs and requirements to increase dramatically when turning to a health-oriented, herbal approach.

One of the best ways to ingest lapacho is in tea form, either with tea bags, or in a loosely cut and sifted, or "bulk" form. Using bulk presents problems of filtering out the fiber. The use of the South American "bombilla," a metal straw with a filter on one end, normally used for drinking yerbamate, neatly solves this problem.

Capsules are also available, but are not nearly as effective as the tea. One of the most intriguing routes of administration is the recent introduction to the marketplace of a mist that is simply sprayed into the mouth and rapidly absorbed directly into the bloodstream.
It is highly recommended by this author as well as folklore wisdom that lapacho be routinely combined with yerbamate. The reasoning, based on centuries of experience in these matters by South American natives, is that the yerbamate has an activating effect on the actions of lapacho. Yerbamate, of course, imparts a good deal of medicinal action itself, as discussed in my booklet: "YerbaMate: Unequaled Natural Nutrition."

CONCLUSION
Throughout the width and breadth of the earth there exist plants with the amazing ability to cure and prevent the ills of mankind when used with wisdom. They grow and blossom and concentrate valuable healing nutrients within their tissues. It is the obligation of animals and people to discover these properties and utilize them in the manner intended by the governing and organizing principles of nature. The search does not begin nor end in a research laboratory. It begins with the experimentation of simple people living close to the earth, who invest nothing in their search save the desire to live healthy, prevent sickness and cure disease. It ends when the rest of the world accepts knowledge so gained, and incorporates it into their own health system.
The need for scientific examination results in the accumulation of interesting and sometimes useful data; at its best it opens new avenues for effective application of the wisdom of the ancients. At its worst, it asks the wrong questions, obtains the wrong answers, becomes puffed up by its own importance, and gets in the way of man's quest for the discovery of nature's healing gifts.
Science and folklore need not clash. When they do, it is usually because the wrong questions were asked, the wrong answers obtained, the wrong materials examined, the wrong people involved. Lapacho currently finds itself in the middle of worldwide confusion. As data showing the efficacy of lapacho accumulates in some areas of the world, other areas continue to ignore basic sources of information; data gathered in such a vacuum disappoints the mind and obstructs progress.

We prefer to believe that lapacho, given enough time, will emerge into the full light of day, even from the dark and muddling laboratories of the United States, and will take its rightful place as one of the great healing herbs of the world. We prefer to believe that until then the herb will be immune to the dealings of dim and uninspired regulatory proceedings on bright continents. We prefer to believe that, in the end, the millions of lapacho users will prevail.
Dr. Mowry is Director of the Mountainwest Institute of Herbal Sciences, in Salt Lake City, Utah.
All information on this page is for educationally purposes only and
Meadowsweet Acres Herbs will not be responsible for any information on this page.